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SOX10 Mouse anti-Human, Mouse, Clone: SOX10/991, Novus Biologicals™
Mouse Monoclonal Antibody
Marca: Novus Biologicals NBP2-59620-100UG
Código de producto. 18246833
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549.00€
518.70€ / 100 microgramos
Ahorro 30.30€
5% Descuento
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Descripción
SOX10 Monoclonal specifically detects SOX10 in Human, Mouse samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array, Flow (Intracellular).
Especificaciones
| SOX10 | |
| Monoclonal | |
| 0.2 mg/mL | |
| Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, Immunohistochemistry-Paraffin 0.5-1 ug/ml, SDS-Page, Protein Array 1:100-1:2000 | |
| MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of | |
| Mouse | |
| 54 kDa | |
| 100 μg | |
| Primary | |
| The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ∼55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG -box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells | |
| Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | |
| IgG2b κ |
| Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), SDS-Page | |
| SOX10/991 | |
| Unconjugated | |
| 10mM PBS with 0.05% BSA with 0.05% Sodium Azide | |
| SOX10 | |
| Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietar | |
| Protein A or G purified | |
| RUO | |
| 6663 | |
| Human, Mouse | |
| Purified |
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Título del producto
For Research Use Only
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