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  6. SOX10 Mouse anti-Human, Mouse, Clone: SOX10/991, Novus Biologicals™

SOX10 Mouse anti-Human, Mouse, Clone: SOX10/991, Novus Biologicals™

Código de producto. 18208634 Tienda Bio Techne Productos
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Cantidad:
100 μg
20 μg
Tamaño de la unidad:
100 microgramos
20 microgramos
Código de producto. Cantidad unitSize
18208634 20 μg 20 microgramos
18246833 100 μg 100 microgramos
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Código de producto. 18208634

Marca: Novus Biologicals NBP25962020UG

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Beschreibung

Mouse Monoclonal Antibody

SOX10 Monoclonal specifically detects SOX10 in Human, Mouse samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array, Flow (Intracellular).
TRUSTED_SUSTAINABILITY

Spezifikation

Antígeno SOX10
Aplicaciones Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), SDS-Page
Clasificación Monoclonal
Clon SOX10/991
Concentración 0.2 mg/mL
Conjugado Unconjugated
Dilución Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, Immunohistochemistry-Paraffin 0.5-1 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Formulación 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Alias de gen MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of
Símbolos de los genes SOX10
Especie del huésped Mouse
Inmunógeno Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietar
Peso molecular del antígeno 54 kDa
Método de purificación Protein A or G purified
Cantidad 20 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 6663
Especificidad de la prueba The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ∼55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG -box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells
Especies diana Human, Mouse
Contenido y almacenamiento Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Formulario Purified
Isotype IgG2b κ
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