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Invitrogen™ Human SIK1, GST Tag Recombinant Protein

Código de producto. p-7121900
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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Código de producto. Cantidad unitSize
15479053 100 μg 100 microgramos
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Código de producto. 15479053 Proveedor Invitrogen™ N.º de proveedor PV6446

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Descripción

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This recombinant human SIK1 (1-303) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Validated in LanthaScreen™ Kinase Binding Assay Protocols available for simple use and optimized performance Learn more about our kinase proteins > Related Links:LanthaScreen™ Kinase Activity AssayLanthaScreen™ Eu Kinase Binding Assay Protein Form: Recombinant, Active, Catalytic The gene accession number for SIK1 is NP_775490.2.

SIK1 may mediate the physiological effects of LKB1, including its tumor suppressor function. SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P57059
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50mM tris HCl with 150mM NaCl, 10mM glutathione, 0.25mM DTT, 25% glycerol, 0.1mM PMSF, 0.1mM EDTA and no preservative; pH 7.5
ID de gen (Entrez) 150094
Peso molecular 61 kDa
Nombre Human SIK1, GST Tag
Intervalo de pH 7.5
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen EIEE30; HRT-20; Kid2; MSK; Myocardial SNF1-like kinase; Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase); protein kinase KID2; salt inducible kinase 1; salt-inducible kinase 1; salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK; SIK; Sik1; SIK-1; SNF1-like kinase; SNF1LK
Nombre común SIK1
Símbolo de gen SIK1
Longitud de la proteína 1-303
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína GST-tag
Secuencia 1-303
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Grupo de cinasas Serine/Threonine Kinase
Sistema de expresión Baculovirus
Familia de proteínas Kinases & Inhibitors
Forma de proteína Recombinant, Catalytic Domain
Formulario Liquid
Categoría de investigación Drug Development, Signal Transduction
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