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Eurofins DiscoverX SHP-1 Protein

Product Code. 17320394
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Cantidad:
10 μg
125 μg
Unit Size:
10 microgramos
125 microgramos
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17320394 10 μg 10 microgramos
17330394 125 μg 125 microgramos
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Product Code. 17320394 Supplier Eurofins DiscoverX Supplier No. 14591

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Description

N-terminal GST-tagged recombinant human full-length SHP-1, for use in Phosphatase Assays.

SHP-1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

GenBank NM_002831

Specifications

Formulación mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 10% glycerol, 0.1 mM EGTA, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Peso molecular 95 kDa
Cantidad 10 μg
Especie Human
Recombinante Recombinant
Etiqueta de proteína N-terminal GST
Sistema de expresión Recombinant enzyme expressed in E. coli cells
Forma de proteína Full-length
Grado de pureza o calidad ≥54%
Expresión SHP-1, active
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