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PMEL17/SILV Antibody (HMB45 + PMEL/783), DyLight 650, Novus Biologicals™
Mouse Monoclonal Antibody
Marca: Novus Biologicals NBP2-47780C
Código de producto. 18130939
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648.00€
612.15€ / 0.10 ml
Ahorro 35.85€
5% Descuento
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Descripción
PMEL17/SILV Monoclonal specifically detects PMEL17/SILV in Human samples. It is validated for Western Blot.
Especificaciones
| PMEL17/SILV | |
| Monoclonal | |
| DyLight 650 | |
| 50mM Sodium Borate with 0.05% Sodium Azide | |
| PMEL | |
| Extract of pigmented melanoma metastases from lymph nodes (HMB45); Recombinant human SILV protein (PMEL/783) (Uniprot: P40967) | |
| 0.1 mL | |
| 6490 | |
| Human | |
| Purified |
| Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence | |
| HMB45 + PMEL/783 | |
| Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence | |
| D12S53EP1, gp100, ME20, ME20-M, melanocyte protein mel 17, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, melanosomal matrix protein17, PMEL17P100, premelanosome proteinME20M, SI, SIL, silver (mouse homolog) like, silver homolog (mouse), Silver locus protein homolog, silver, mouse, homolog of, SILVPmel17 | |
| Mouse | |
| Protein A or G purified | |
| Primary | |
| The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60-64 kDa), which is subsequently cleaved to generate 26kDa and 34-38kDa. By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This monoclonal antibody reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This monoclonal antibody stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This monoclonal antibody also stains Angiomyolipoma (PEComa). | |
| Store at 4C in the dark. | |
| IgG1 κ |
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