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Eurofins DiscoverX PI3 Kinase (p120γ) Protein
Descripción
PI3 Kinase (p120γ) belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
GenBank AF327656. The recombinant protein contains the amino acid substitution R459Q with respect to this accession number. This conflict is reported in GenBank XM_027912. The residue coordinates in the native sequence are given.
Especificaciones
Especificaciones
| Formulación | mg/mL of enzyme in 50mM Tris/HCl pH7.5, 150mM NaCl, 10% glycerol, 0.1mM EGTA, 2mM DTT. |
| Peso molecular | 130 kDa |
| Cantidad | 20 μg |
| Especie | Human |
| Recombinante | Recombinant |
| Etiqueta de proteína | N-terminal 6His |
| Sistema de expresión | Recombinant enzyme expressed in Sf21 insect cells |
| Forma de proteína | Full-length |
| Grado de pureza o calidad | ≥66% |
| Expresión | PI3 Kinase (p120γ) |
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