Gibco™ PeproGMP™ Human TPO (Thrombopoietin) Recombinant Protein, PeproTech®

Recombinant Protein

Thrombopoietin (TPO) is a hematopoietic growth factor that stimulates the proliferation and maturation of megakaryocytes. The human TPO gene encodes for a 353 amino acid glycoprotein, which contains a 21 amino acid signal sequence, a 15 amino acid erythropoietin-like domain, and a highly glycosylated 179 amino acid C-terminal domain. PeproTech Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. PeproGMP TPO cytokine is most often used with PeproGMP SCF and PeproGMP Flt3-ligand in ex-vivo cell therapy for the proliferation of hematopoietic stem cell (HSC) cultures, along with IL-3 and IL-6 for further synergistic expansion and immune cell maturation. Reconsitute using sterile water (i.e., WFI) to a concentration of 0.5-1.0 mg/ml. Additional product information , specifications, handling and reconstitution information are provided on the Certificate of Analysis. All PeproGMP™ products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.