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Gibco™ PeproGMP® Human SCF Recombinant Protein, PeproTech®

Código de producto. 30276212
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Cantidad:
100 μg
1 mg
50 μg
Tamaño de la unidad:
1 miligramo
100 microgramos
50 microgramos
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Código de producto. Cantidad unitSize
30276212 50 μg 50 microgramos
30275009 1 mg 1 miligramo
30276211 100 μg 100 microgramos
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Código de producto. 30276212 Proveedor Gibco™ N.º de proveedor GMP3000750UG

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Descripción

Recombinant Protein

The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P21583
Para utilizar con (aplicación) Control, Western Blot Control, Bioactivity
Formato Lyophilized
Formulación Protein with no preservative
ID de gen (Entrez) 4254
Peso molecular 18.4 kDa
Nombre PeproGMP™ Human SCF
Método de purificación Purified
Cantidad 50 μg
Requisitos de almacenamiento -20°C or -80°C if preferred
Estado normativo GMP
Concentración de endotoxinas ≤0.1 EU/μg
Alias de gen 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Nombre común SCF
Símbolo de gen KITLG
Actividad biológica Determined by the proliferation of TF-1 cells. PeproGMP Recombinant Human SCF has been tested against the WHO standard NIBSC 91/682.
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA
Contenido y almacenamiento -20°Cor to +80°C if preferred
Actividad Determined by the proliferation of TF-1 cells. PeproGMP Recombinant Human SCF has been tested against the WHO standard NIBSC 91/682. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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