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Gibco™ PeproGMP™ Human LIF Recombinant Protein, PeproTech®

Código de producto. 30276441
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Cantidad:
100 μg
50 μg
Tamaño de la unidad:
100 microgramos
50 microgramos
Código de producto. Cantidad unitSize
30276441 50 μg 50 microgramos
30275502 100 μg 100 microgramos
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Código de producto. 30276441

Marca: Gibco™ GMP3000550UG

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Descripción

Recombinant Protein

PeproTech Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds. Reconstitute using sterile water (i.e., WFI) to a concentration of 0.1-1.0 mg/ml. Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis. All PeproGMP™ products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P15018
Para utilizar con (aplicación) Control, Western Blot Control, Bioactivity
Formato Lyophilized
Formulación Protein with no preservative
ID de gen (Entrez) 3976
Peso molecular 19.7 kDa
Nombre PeproGMP™ Human LIF
Método de purificación Purified
Cantidad 50 μg
Requisitos de almacenamiento -20°C or -80°C if preferred
Estado normativo GMP
Concentración de endotoxinas ≤0.1 EU/μg
Alias de gen CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Nombre común LIF
Símbolo de gen Lif
Actividad biológica Determined by the proliferation of TF-1 cells.
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Contenido y almacenamiento -20°Cor to +80°C if preferred
Actividad Determined by the proliferation of TF-1 cells.
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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