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Gibco™ PeproGMP™ Human Activin A Recombinant Protein, PeproTech®

Código de producto. 30275960
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Cantidad:
100 μg
50 μg
Tamaño de la unidad:
100 microgramos
50 microgramos
Código de producto. Cantidad unitSize
30275960 100 μg 100 microgramos
30275493 50 μg 50 microgramos
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Código de producto. 30275960

Marca: Gibco™ GMP12014E100UG

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Descripción

Recombinant Protein

PeproTech Recombinant Human Activin A is a 26.0 kDa disulfide-linked homodimer of two beta-A chains, each containing 116 amino acid residues. Reconstitute using sterile water (i.e., WFI) to a concentration of 0.1-1.0 mg/ml. Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis. All PeproGMP™ products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P08476
Para utilizar con (aplicación) Control, Western Blot Control, Bioactivity
Formato Lyophilized
Formulación Protein with no preservative
ID de gen (Entrez) 3624
Peso molecular 26 kDa
Nombre PeproGMP™ Human Activin A
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -20°C or -80°C if preferred
Estado normativo GMP
Concentración de endotoxinas ≤0.1 EU/μg
Alias de gen activin A; activin beta-A chain; BMP7; BMP-7; Bone morphogenetic protein 7; EDF; Eptotermin alfa; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FRP; FSH-releasing protein; INHB; Inhba; inhibin B subunit; inhibin beta A chain; inhibin beta A protein; inhibin beta A subunit; inhibin beta-A; inhibin beta-A-subunit; inhibin beta-subunit; inhibin subunit beta A; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; OP1; OP-1; Osteogenic protein 1; unnamed protein product
Nombre común Activin A
Símbolo de gen Inhba
Actividad biológica Determined by the proliferation of mouse MPC-11 cells. PeproGMP Recombinant Human Activin A has been tested against the WHO standard NIBSC 91/626.
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Contenido y almacenamiento -20°Cor to +80°C if preferred
Actividad Determined by the proliferation of mouse MPC-11 cells. PeproGMP Recombinant Human Activin A has been tested against the WHO standard NIBSC 91/626. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Sistema de expresión E. coli
Formulario Lyophilized
Línea de productos PeproGMP
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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