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p53 Mouse, Clone: DO-7, Novus Biologicals™

Código de producto. 18765843 Tienda Bio Techne Productos
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Cantidad:
0.02 mg
0.1 mg
Tamaño de la unidad:
0.02 miligramo
0.10 miligramo
Código de producto. Cantidad unitSize
18765843 0.1 mg 0.10 miligramo
18122265 0.02 mg 0.02 miligramo
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Código de producto. 18765843

Marca: Novus Biologicals NBP2343080.1mg

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Descripción

Mouse Monoclonal Antibody

p53 Monoclonal specifically detects p53 in Human, Bovine, Monkey samples. It is validated for Western Blot, Simple Western, Immunohistochemistry, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno p53
Aplicaciones Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Clasificación Monoclonal
Clon DO-7
Conjugado Unconjugated
Dilución Western Blot 0.5-1.0ug/ml, Simple Western 10 ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
Formulación PBS with 0.05% BSA. with 0.05% Sodium Azide
N.º de referencia del gen P04637
Alias de gen Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
Símbolos de los genes TP53
Especie del huésped Mouse
Inmunógeno Recombinant human wild type p53 protein expressed in E. coli.
Peso molecular del antígeno 53 kDa
Método de purificación Protein A purified
Cantidad 0.1 mg
Estado normativo RUO
Disciplina de investigación Apoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Primario o secundario Primary
ID de gen (Entrez) 7157
Especificidad de la prueba Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Especies diana Human, Bovine, Primate
Contenido y almacenamiento Store at 4C.
Formulario Purified
Isotype IgG2b κ
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