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NOTCH3 Recombinant Polyclonal Antibody (4HCLC), Invitrogen™

Rabbit Recombinant Polyclonal Antibody

Marca:  Invitrogen 711007

Código de producto. 15607758

  • 514.00€ / 100 microgramos
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Descripción

Descripción

This antibody is predicted to react with Monkey, Bovine, Cat and Rat. Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
TRUSTED_SUSTAINABILITY
Especificaciones

Especificaciones

NOTCH3
Recombinant Polyclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q61982, Q9UM47
Notch3
Peptides corresponding to Human NOTCH3 (aa 2308-2321, 1618-1636, 1803-1816)
100 μg
Primary
Human, Mouse
Antibody
IgG
Western Blot
4HCLC
Unconjugated
Notch3
AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3
Rabbit
Protein A
RUO
18131, 4854
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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Título del producto
NOTCH3 Recombinant Polyclonal Antibody (4HCLC), Invitrogen™ > 100 μg; Unconjugated

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