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MUC1 Antibody (MUC1/955), Alexa Fluor™ 350, Novus Biologicals™

Código de producto. 18133648 Tienda Bio Techne Productos
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0.1 mL
Tamaño de la unidad:
0.10 ml
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Código de producto. 18133648 Proveedor Novus Biologicals N.º de proveedor NBP247884AF350

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Descripción

Mouse Monoclonal Antibody

MUC1 Monoclonal specifically detects MUC1 in Human, Mouse samples. It is validated for Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno MUC1
Aplicaciones Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Clasificación Monoclonal
Clon MUC1/955
Conjugado Alexa Fluor 350
Dilución Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulación 50 mM sodium borate with 0.05% sodium azide
Alias de gen Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Símbolos de los genes MUC1
Especie del huésped Mouse
Inmunógeno Human milk-fat globule membranes (HMFGM) (Uniprot: P15941)
Método de purificación Protein A or G purified
Cantidad 0.1 mL
Disciplina de investigación Cancer, Cellular Markers, Extracellular Matrix, Inflammation, Signal Transduction
Primario o secundario Primary
ID de gen (Entrez) 4582.0
Especificidad de la prueba This monoclonal antibody reacts with MUC1. The dominant epitope of this monoclonal antibody has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Especies diana Human, Mouse
Contenido y almacenamiento Store at 4°C in the dark.
Isotype IgG1 κ
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