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Gibco™ Mouse IL-1 beta Recombinant Protein, PeproTech®
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Cantidad:
10 μg
100 μg
2 μg
2 x 500 μg
250 μg
50 μg
500 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
2 microgramos
250 microgramos
50 microgramos
500 microgramos
paquete de 2
Descripción
211-11B-1MG will be provided as 2 x 500 μg (211-11B-500UG). Recombinant Murine IL-1beta is a 17.5 kDa protein containing 153 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Especificaciones
Especificaciones
Número de acceso | P10749 |
Para utilizar con (aplicación) | ELISA, Functional Assay, Western Blot |
Formulación | protein with no preservative |
ID de gen (Entrez) | 16176 |
Peso molecular | 17.5 kDa |
Nombre | Mouse IL-1 beta |
Cantidad | 2 x 500 μg |
Fuente | E. coli |
Estado normativo | RUO |
Concentración de endotoxinas | <1 EU/ μg |
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Título del producto
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