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Invitrogen™ Human MET [M1250T], His Tag Recombinant Protein
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Cantidad:
100 μg
1 mg
Tamaño de la unidad:
1 miligramo
100 microgramos
Descripción
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Cytoplasmic
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Especificaciones
Especificaciones
| Concentración | See Label |
| Para utilizar con (aplicación) | Kinase Assay |
| Formulación | 50 mM tris HCl with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5 |
| Peso molecular | 53.7 kDa |
| Nombre | Human MET [M1250T], His Tag |
| Cantidad | 100 μg |
| Estado normativo | RUO - research use only |
| Nombre común | MET (M1250T Mutant) |
| Familia Quinasa | MET (HGFR) Kinase Family |
| Longitud de la proteína | 956-1390; M1250T |
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