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LAG-3 (CD223) Mouse anti-Human, APC-R700, Clone: T47-530, BD

Mouse Monoclonal Antibody

322.00€ - 635.00€

Especificaciones

Antígeno LAG-3 (CD223)
Clon T47-530
Clasificación Monoclonal
Conjugado APC-R700
Especie del huésped Mouse
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15884509
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BD Biosciences
565775
25 Tests
322.00€
cada uno
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Fecha estimada de envío: 20-06-2024
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15874509
Ver documentos Detalles de la promoción
BD Biosciences
565774
100 Tests
635.00€
cada uno
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 20-06-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

The T47-530 specifically recognizes the Lymphocyte Activation Gene 3 (LAG-3) protein which is also known as, Protein FDC, or CD223. LAG-3 is a ñ70 kDa type I transmembrane glycoprotein that belongs to the Ig superfamily and exhibits homology to CD4. LAG-3 is expressed on NK cells, regulatory T cells, and activated conventional T cells with higher expression found on CD8+ T cells compared with CD4+ T cells. LAG-3 is an activation induced cell surface molecule that like CD4, binds MHC class II molecules, but with much higher affinity. This may enable LAG-3 to act as a negative competitor of CD4 for MHC class II ligand binding. LAG-3 may associate with the TCR-CD3 complex to downregulate TCR signal transduction and T cell clonal expansion. In contrast, LAG-3-induced signaling may promote dendritic cell activation.

This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45nm filter). APC-R700 is a tandem fluorochrome that combines APC with R700, a proprietary organic dye. This dye has been developed exclusively by BD Biosciences as a brighter alternative to Alexa Fluor™ 700. Due to similar excitation and emission properties, APC-R700 and Alexa Fluor™ 700 cannot be used simultaneously.
Especificaciones

Especificaciones

LAG-3 (CD223)
Monoclonal
Mouse
Human
LAG3, CD223, FDC, Lymphocyte activation gene 3 protein, Protein FDC
IgG1 κ
Affinity Purified
T47-530
APC-R700
RUO
Aqueous buffered solution containing BSA, protein stabilizer, glycerol and ≤0.09% sodium azide.
Human LAG-3 Recombinant Protein
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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