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LAG-3 (CD223) Mouse anti-Human, APC-R700, Clone: T47-530, BD
Mouse Monoclonal Antibody
322.00€ - 635.00€
Especificaciones
Antígeno | LAG-3 (CD223) |
---|---|
Clon | T47-530 |
Clasificación | Monoclonal |
Conjugado | APC-R700 |
Especie del huésped | Mouse |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15884509
|
BD Biosciences
565775 |
25 Tests |
322.00€
cada uno |
Fecha estimada de envío: 21-08-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
15874509
|
BD Biosciences
565774 |
100 Tests |
635.00€
cada uno |
Fecha estimada de envío: 21-08-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
The T47-530 specifically recognizes the Lymphocyte Activation Gene 3 (LAG-3) protein which is also known as, Protein FDC, or CD223. LAG-3 is a ñ70 kDa type I transmembrane glycoprotein that belongs to the Ig superfamily and exhibits homology to CD4. LAG-3 is expressed on NK cells, regulatory T cells, and activated conventional T cells with higher expression found on CD8+ T cells compared with CD4+ T cells. LAG-3 is an activation induced cell surface molecule that like CD4, binds MHC class II molecules, but with much higher affinity. This may enable LAG-3 to act as a negative competitor of CD4 for MHC class II ligand binding. LAG-3 may associate with the TCR-CD3 complex to downregulate TCR signal transduction and T cell clonal expansion. In contrast, LAG-3-induced signaling may promote dendritic cell activation.
This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45nm filter). APC-R700 is a tandem fluorochrome that combines APC with R700, a proprietary organic dye. This dye has been developed exclusively by BD Biosciences as a brighter alternative to Alexa Fluor™ 700. Due to similar excitation and emission properties, APC-R700 and Alexa Fluor™ 700 cannot be used simultaneously.Especificaciones
LAG-3 (CD223) | |
Monoclonal | |
Mouse | |
Human | |
LAG3, CD223, FDC, Lymphocyte activation gene 3 protein, Protein FDC | |
IgG1 κ | |
Affinity Purified |
T47-530 | |
APC-R700 | |
RUO | |
Aqueous buffered solution containing BSA, protein stabilizer, glycerol and ≤0.09% sodium azide. | |
Human LAG-3 Recombinant Protein | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |