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Isocitrate Dehydrogenase 1/IDH1 Antibody (IDH1/1152) - IHC-Prediluted, Novus Biologicals™
Mouse Monoclonal Antibody
Marca: Novus Biologicals NBP2-48302
Product Code. 18114589
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498.00€
470.40€ / 7 ml
Ahorro 27.60€
5% Descuento
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Description
Isocitrate Dehydrogenase 1/IDH1 Monoclonal specifically detects Isocitrate Dehydrogenase 1/IDH1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Specifications
| Isocitrate Dehydrogenase 1/IDH1 | |
| Monoclonal | |
| Unconjugated | |
| 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
| IDH1 | |
| Recombinant fragment of human Isocitrate Dehydrogenase 1/IDH1 protein (around aa 281-414) (exact sequence is proprietary) (Uniprot: O75874 ) | |
| Protein A or G purified | |
| RUO | |
| Primary | |
| It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway. | |
| Store at 4C. | |
| IgG1 κ |
| Immunohistochemistry (Paraffin) | |
| IDH1/1152 | |
| Immunohistochemistry-Paraffin | |
| Cytosolic NADP-isocitrate dehydrogenase, EC 1.1.1.42, IDCD, IDH, IDP, IDPC, isocitrate dehydrogenase [NADP] cytoplasmic, isocitrate dehydrogenase 1 (NADP+), soluble, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, Oxalosuccinate decarboxylase, PICD | |
| Mouse | |
| 46 kDa | |
| 7 mL | |
| Stem Cell Markers | |
| 3417 | |
| Human | |
| Purified |
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