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Descripción
IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity (PMID: 21986312, 22174445, 19819937, 16895557)
Especificaciones
Especificaciones
| Número de acceso | P05113 |
| Formulación | 1 x PBS |
| ID de gen (Entrez) | 3567 |
| Peso molecular | 35-38 kDa |
| Cantidad | 100 μg |
| Fuente | HEK293 |
| Requisitos de almacenamiento | Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.) |
| Concentración de endotoxinas | <0.1 EU/μg |
| Reactividad específica | Human |
| Recombinante | Recombinant |
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Título del producto
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