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Invitrogen™ Human VEGFR3 (Flt-4) Fc Chimera Recombinant Protein

Código de producto. 17945711
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Cantidad:
100 μg
1 mg
Tamaño de la unidad:
1 miligramo
100 microgramos
Código de producto. Cantidad unitSize
17945711 100 μg 100 microgramos
17925611 1 mg 1 miligramo
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Código de producto. 17945711

Marca: Invitrogen™ RP88179

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Descripción

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (900 μL) be added to the vial to prepare a stock solution of 1.11 mg/mL. Concentration is measured by UV.

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P35916
Para utilizar con (aplicación) Control, ELISA Standard, Binding Assay
Formato Lyophilized
Formulación PBS with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
ID de gen (Entrez) 2324
Peso molecular 111.3 kDa
Nombre Human VEGFR3 (Flt-4) Fc Chimera
Intervalo de pH 7.4
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -20°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Concentración de endotoxinas <1.0 EU/μg
Alias de gen AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3
Nombre común VEGF Receptor 3
Símbolo de gen FLT4
Actividad biológica Measured by its binding ability in a functional ELISA. 1. Immobilized recombinant human VEGFR3 at 5 μg/ml (100 μL/well) can bind recombinant human VEGF-D at a linear range of 62.5-2000 ng/mL 2. Immobilized recombinant human VEGF-C at 10 μg/ml (100 μL/well) can bind recombinant human VEGFR3 (at a linear range of 0.64-80 ng/mL 3. Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM.)
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Etiqueta de proteína Fc-tag
Secuencia Human VEGFR3, amino acids Met1-Ile776 (Accession # NP_002011.2) with a C-terminal human IgG1 Fc region
Contenido y almacenamiento -20°C, Avoid Freeze/Thaw Cycles
Actividad Measured by its binding ability in a functional ELISA. 1. Immobilized recombinant human VEGFR3 at 5 μg/ml (100 μL/well) can bind recombinant human VEGF-D at a linear range of 62.5-2000 ng/mL. 2. Immobilized recombinant human VEGF-C at 10 μg/ml (100 μL/well) can bind recombinant human VEGFR3 at a linear range of 0.64-80 ng/mL. 3. Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM.
Sistema de expresión HEK293 cells
Formulario Lyophilized
Grado de pureza o calidad >97% as determined by SDS-PAGE.
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