missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Proteínas recombinantes
  4. 10690544

Gibco™ Human TRAIL (TNFSF10) Recombinant Protein

Código de producto. 10690544
Change view
Click to view available options
Cantidad:
50 μg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10690544 50 μg cada uno
1 options
Este artículo no se puede devolver. Vea la política de devoluciones

Código de producto. 10690544

Marca: Gibco™ PHC1634

Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.

Este artículo no se puede devolver. Vea la política de devoluciones

Descripción

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile, distilled water to a concentration of 0.5-1.0 mg/mL. Do not vortex. This solution can be stored at 2°C to 8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein, such as 0.1% BSA and store in working aliquots at -20°C to -80°C. Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C for long term storage, preferably desiccated. Working aliquots stored with a carrier protein are stable for at least 12 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles.

TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P50591
Para utilizar con (aplicación) Bioactivity
Formulación 10mM sodium phosphate with 110mM NaCl and no preservative; pH 7.2
ID de gen (Entrez) 8743
Peso molecular 19.6 kDa
Nombre Human TRAIL (TNFSF10)
Intervalo de pH 7.2
Método de purificación Purified
Cantidad 50 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
Nombre común TRAIL (CD253)
Símbolo de gen TNFSF10
Actividad biológica ED50 = 1 - 3 ng/mL; determined by the dose-dependent apoptosis of U34MG cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia Human TRAIL recombinant protein contains 168 amino acids
Contenido y almacenamiento -20°C
Clasificación Carrier-Free
Actividad ED50 = 1 - 3 ng/mL; determined by the dose-dependent apoptosis of U34MG cells.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión E. coli
Familia de proteínas Cytokines & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína Other Proteins
Categoría de investigación Apoptosis, Oncology, Signal Transduction
Línea de productos Gibco
Grado de pureza o calidad ≥98% by SDS-PAGE and HPLC
Mostrar más Mostrar menos
Título del producto
Seleccione un problema

Al hacer clic en Enviar, acepta que Fisher Scientific se ponga en contacto con usted en relación con los comentarios que ha proporcionado en este formulario. No compartiremos su información para ningún otro fin. Toda la información de contacto proporcionada se mantendrá de acuerdo con nuestra Política de Privacidad. Política de privacidad.