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Gibco™ Human TPO (Thrombopoietin) Recombinant Protein

Código de producto. p-5232853
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Cantidad:
100 μg
10 μg
1 mg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
11370842 100 μg cada uno
11380842 1 mg cada uno
11300852 10 μg cada uno
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Código de producto. 11370842

Proveedor: Gibco™ PHC9511

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Description

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized recombinant human Thrombopoietin in PBS containing 0.1% human serum albumin. Further dilutions should be made in low endotoxin medium or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA. Storage: Store this lyophilized preparation at <-20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at <-20°C. Avoid repeated freeze/thaw cycles.

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P40225
Para utilizar con (aplicación) Bioactivity
Formulación PBS with no preservative
ID de gen (Entrez) 7066
Peso molecular 85 kDa
Nombre Human TPO (Thrombopoietin)
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <1 EU/μg
Alias de gen C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX
Nombre común Thrombopoietin
Símbolo de gen THPO
Actividad biológica ED50 = 0.5 - 5 ng/mL; determined by dose-dependent proliferation of human TF-1 cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Contenido y almacenamiento -20°C
Clasificación Carrier-Free
Actividad ED50 = 0.5 - 5 ng/mL; determined by dose-dependent proliferation of human TF-1 cells.
Bioensayo Proliferation of TF1 cells
Nivel de endotoxinas <1 EU/ml
Condiciones de envío Dry Ice
Sistema de expresión HEK293 cells
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína TPO
Categoría de investigación Endocrinology, Stem Cell Research, Angiogenesis
Línea de productos Gibco
Grado de pureza o calidad >90% by SDS-PAGE
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