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Invitrogen™ Human SCF Recombinant Protein

Recombinant Protein

Marca:  Invitrogen™ RSCF10

Detalles adicionales : Peso : 0.80000kg

Código de producto. 11818821

  • 398.00€ / 10 microgramos
Fecha estimada de envío: 13-06-2022
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Descripción

Descripción

Human Stem Cell Factor (SCF) Recombinant Protein, RSCF10, from Invitrogen.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist. Purity: >95% pure by SDS-PAGE analyses. Activity: The biological activity of recombinant human Stem Cell Factor was determined by measuring the proliferation of the factor-dependent human T-helper cell line, TF-1. The ED50 (or 1 unit of activity) for this effect in our laboratories is typically <2ng/ml, corresponding to a specific activity of >5 x10^5 units/mg. Use: For in vitro applications. A dose-response assay should be performed to determine the optimal concentration for specific experiments. Reconstitution and Dilution: Reconstitute lyophilized material in 0.1 ml of 10 mM Acetic acid to a final concentration of 0.1mg/mL. Dilute in a buffer-containing carrier protein, aliquot, and store at or below -70°C. Avoid multiple freeze-thaw cycles. PBS with 1% BSA or a neutral media containing <10% FCS are suitable buffers.
Especificaciones

Especificaciones

P21583
Lyophilized
4254
purified
E. Coli
RUO
Human Stem Cell Factor (SCF)
Human
Hu
Recombinant
Control, ELISA, Immunoprecipitation, Western Blot
Control, ELISA, Immunoprecipitation, Western Blot
0.01M acetic acid with no preservative
Human Stem Cell Factor (SCF)
10μg
-20°C, Avoid Freeze/Thaw Cycles
FPH2; KL-1; Kitl; MGF; SCF; SF; SHEP7; kit-ligand; c-Kit ligand; familial progressive hyperpigmentation 2; kit ligand; mast cell growth factor; steel factor; stem cell factor
KITLG
Unlabeled
E. coli
Recombinant
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