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Gibco™ Human SCF Recombinant Protein
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Cantidad:
100 μg
10 μg
1 mg
25 μg
Tamaño de la unidad:
cada uno
Descripción
Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile deionized water to 0.1-1.0 mg/mL to regain full activity. Make any further dilutions of the reconstituted protein in low endotoxin medium or buffered solution with FBS or tissue culture grade BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Especificaciones
Especificaciones
| Número de acceso | P21583 |
| Para utilizar con (aplicación) | Bioactivity |
| Formulación | Protein with no preservative |
| ID de gen (Entrez) | 4254 |
| Peso molecular | 18.54 kDa |
| Nombre | Human SCF |
| Método de purificación | Purified |
| Cantidad | 100 μg |
| Requisitos de almacenamiento | 4°C |
| Estado normativo | RUO |
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