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Gibco™ Human sCD42b Recombinant Protein, PeproTech®

Código de producto. 17859305
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Cantidad:
100 μg
10 μg
1 mg
250 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
250 microgramos
50 microgramos
500 microgramos
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Código de producto. Cantidad unitSize
17859305 100 μg 100 microgramos
17869535 50 μg 50 microgramos
17829485 500 μg 500 microgramos
17859455 250 μg 250 microgramos
17879565 1 mg 1 miligramo
17839255 10 μg 10 microgramos
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Código de producto. 17859305 Proveedor Gibco™ N.º de proveedor 31048100UG

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Descripción

Recombinant Protein

Recombinant Human sCD42b/GP1Ba is a 54.6 kDa protein containing 496 amino acid residues that correspond to the extracellular portion of CD42b/GP1Ba, plus a C-terminal His-Tag. Due to glycosylation, it migrates at approximately 100-115 kDa by SDS-PAGE analysis under reducing and non-reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P07359
Para utilizar con (aplicación) Functional Assay
Formato Lyophilized
Formulación protein with no preservative
ID de gen (Entrez) 2811
Peso molecular 54.6 kDa
Nombre Human sCD42b
Método de purificación HPLC, SDS-PAGE
Cantidad 100 μg
Estado normativo RUO
Concentración de endotoxinas <1 EU/μg
Alias de gen Antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42a; CD42B; CD42b-alpha; DBPLT3; Glycocalicin; glycoprotein 1 b, alpha polypeptide; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ib platelet subunit alpha; glycoprotein Ibalpha; GP1B; GP1BA; GPIB; GPIb alpha; GP-Ib alpha; GPIbA; GPIbalpha; GPIX; GP-IX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1 b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP
Nombre común CD42b
Símbolo de gen Gp1ba
Actividad biológica Determined by its ability to bind recombinant human von Willebrand Factor-A2 in a functional ELISA.
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Etiqueta de proteína His-tag
Secuencia HPICEVSKVA SHLEVNCDKR NLTALPPDLP KDTTILHLSE NLLYTFSLAT LMPYTRLTQL NLDRCELTKL QVDGTLPVLG TLDLSHNQLQ SLPLLGQTLP ALTVLDVSFN RLTSLPLGAL RGLGELQELY LKGNELKTLP PGLLTPTPKL EKLSLANNNL TELPAGLLNG LENLDTLLLQ ENSLYTIPKG FFGSHLLPFA FLHGNPWLCN CEILYFRRWL QDNAENVYVW KQGVDVKAMT SNVASVQCDN SDKFPVYKYP GKGCPTLGDE GDTDLYDYYP EEDTEGDKVR ATRTVVKFPT KAHTTPWGLF YSWSTASLDS QMPSSLHPTQ ESTKEQTTFP PRWTPNFTLH MESITFSKTP KSTTEPTPSP TTSEPVPEPA PNMTTLEPTP SPTTPEPTSE PAPSPTTPEP TSEPAPSPTT PEPTSEPAPS PTTPEPTPIP TIATSPTILV SATSLITPKS TFLTTTKPVS LLESTKKTIP ELDQPPKLHH HHHHHH
Contenido y almacenamiento -20°C
Actividad Determined by its ability to bind recombinant human von Willebrand Factor-A2 in a functional ELISA.
Sistema de expresión CHO cells
Formulario Lyophilized
Grado de pureza o calidad ≥95% by SDS-PAGE gel and HPLC analyses.
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