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STEMCELL Technologies Human Recombinant IL-7, ACF
Descripción
- Interleukin 7 (IL-7) is a member of the type I cytokine family that is critical for T and B cell development and survival
- It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.) IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways
- IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and regulatory T cells (Carrette & Surh)
- Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige)
- This product is animal component-free
Especificaciones
Especificaciones
| Nombre | Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor |
| Cantidad | 100 μg |
| Tipo de célula | Hematopoietic Stem and Progenitor Cells |
| Grado de pureza o calidad | ≥95% |
Título del producto
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