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STEMCELL Technologies Human Recombinant IL-6R alpha

Código de producto. 17129531
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Cantidad:
50 μg
Tamaño de la unidad:
50 microgramos
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Product Code. 17129531

missing translation for 'mfr': STEMCELL Technologies 78083.1

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Description

Interleukin 6 receptor alpha

  • Interleukin 6 receptor (IL-6R) alpha is a type I transmembrane glycoprotein that forms a complex with type I transmembrane signal transducer protein gp130 (CD130) and mediates the biological activities of IL-6
  • IL-6 binds to the membrane-bound non-signaling IL-6R alpha (mIL-6R), and the complex binds to two molecules of gp130 and leads to ‘classical' IL-6-signal transduction, which includes activation of JAK/STAT, ERK, and PI3K signal transduction pathways
  • In contrast, a soluble form of IL-6R alpha (sIL-6R), which comprises the extracellular portion of the receptor, binds to the secreted IL-6 to form a complex that promotes bioavailability of IL-6
  • The complex of IL-6 and sIL-6R can bind to gp130 on cells that do not express the IL-6R and are unresponsive to IL-6
  • This process is known as trans-signaling

Specifications

Nombre B cell stimulatory factor-2, CD126, IL-6R, IL-6R1, IL-6RA, Interleukin-6 receptor, Interleukin-6 receptor alpha
Cantidad 50 μg
Grado de pureza o calidad ≥95%
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