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STEMCELL Technologies Human Recombinant IL-2, ACF
Descripción
- Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor
- It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132
- Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.) The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts
- IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ T regulatory cells and affects development of follicular helper T cells
- IL-2 also controls inflammation by inhibiting Th17 differentiation
- This product is animal component-free
Especificaciones
Especificaciones
| Nombre | Aldesleukin, Interleukin-2, T cell growth factor, TCGF |
| Cantidad | 10 μg |
| Tipo de célula | Hematopoietic Stem and Progenitor Cells; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+ |
| Grado de pureza o calidad | ≥95% |
Título del producto
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