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STEMCELL Technologies Human Recombinant IL-1 beta, ACF
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Cantidad:
1000 μg
100 μg
10 μg
Tamaño de la unidad:
10 microgramos
100 microgramos
1000 microgramos
Descripción
- Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β
- This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.) IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway
- IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins
- It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells
- IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen
- It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner
- This product is animal component-free
Especificaciones
Especificaciones
| Nombre | Catabolin, Endogenous pyrogen, EP, Interleukin-1 beta, LAF, LEM, Leukocyte endogenous mediator, Lymphocyte-activating factor, MCF, Mononuclear cell factor |
| Cantidad | 10 μg |
| Tipo de célula | B Cells; Hematopoietic Stem and Progenitor Cells; T Cells; T Cells, CD4+; T Cells, CD8+ |
| Grado de pureza o calidad | ≥95% |
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