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Invitrogen™ Human PDE8B (aa 374-440) Control Fragment Recombinant Protein
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
Descripción
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83361 (PA5-83361. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
Especificaciones
Especificaciones
| Número de acceso | O95263 |
| Concentración | ≥5.0 mg/mL |
| Para utilizar con (aplicación) | Blocking Assay, Control |
| Formulación | 1 M urea, PBS with no preservative; pH 7.4 |
| ID de gen (Entrez) | 8622 |
| Nombre | Human PDE8B (aa 374-440) Control Fragment |
| Cantidad | 100 μL |
| Estado normativo | RUO |
| Alias de gen | 3',5' cyclic nucleotide phosphodiesterase 8 B; ADSD; B230331L10Rik; C030047E14Rik; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 B; hsPDE8B; Pde8b; phosphodiesterase 8 B; PIG22; PPNAD3; RNPDE8B |
| Nombre común | PDE8B |
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