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Gibco™ Human/Mouse/Rat BDNF Recombinant Protein, PeproTech®

Código de producto. 17854253
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Cantidad:
100 μg
10 μg
1 mg
250 μg
2 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
2 microgramos
250 microgramos
50 microgramos
500 microgramos
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Código de producto. 17854253

Marca: Gibco™ 45002500UG

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2660.00 EUR hasta el 2026-06-30
MEJOR PRECIO en promoción! Use el código promocional "27928" para aplicar la oferta.
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Descripción

Recombinant Protein

Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P21237, P23363, P23560
Para utilizar con (aplicación) ELISA, Functional Assay, Western Blot
Formulación protein with no preservative
ID de gen (Entrez) 12064, 24225, 627
Peso molecular 27 kDa
Nombre Human/Mouse/Rat BDNF
Cantidad 500 μg
Fuente E. coli
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Nombre común BDNF
Símbolo de gen BDNF
Actividad biológica Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Conjugado Unconjugated
Recombinante Recombinant
Secuencia MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Contenido y almacenamiento -20°C
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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