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Gibco™ Human LIF Recombinant Protein

Código de producto. 13310955
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Cantidad:
1000 μg
100 μg
10 μg
Unit Size:
1 miligramo
10 microgramos
100 microgramos
Product Code. Cantidad unitSize
13310955 10 μg 10 microgramos
13330595 100 μg 100 microgramos
13360765 1000 μg 1 miligramo
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Product Code. 13310955

Brand: Gibco™ PHC9484

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Description

Recombinant Protein

Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water or appropriate buffered solution containing 0.1% BSA to regain full activity. Apportion there constituted protein into working aliquots and store at -20°C. Make any further dilutions of the reconstituted protein in buffered solution containing a carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles.

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P15018
Para utilizar con (aplicación) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulación protein with no preservative
ID de gen (Entrez) 3976
Peso molecular 21 kDa
Nombre Human LIF
Método de purificación Sequential Chromatography
Cantidad 10 μg
Concentración de endotoxinas <0.1 ng/μg
Alias de gen CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Nombre común LIF
Símbolo de gen LIF
Actividad biológica ED50 = 0.05 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia PLPITPVNAT CAIRHPCHNN LMNQIRSQLA QLNGSANALF ILYYTAQGEP FPNNLDKLCG PNVTDFPPFH ANGTEKAKLV ELYRIVVYLG TSLGNITRDQ KILNPSALSL HSKLNATADI LRGLLSNVLC RLCSKYHVGH VDVTYGPDTS GKDVFQKKKL GCQLLGKYKQ IIAVLAQAF
Contenido y almacenamiento 4°C
Actividad 0.5 ng/ml
Bioensayo Dose-dependent proliferation of TF-1 cells
Condiciones de envío Dry Ice
Sistema de expresión E. coli
Familia de proteínas Cytokines & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína Other Cytokines
Categoría de investigación Oncology
Línea de productos Gibco
Grado de pureza o calidad ≥95% by SDS-PAGE
Expresión Leukemia inhibitory factor
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