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Invitrogen™ Human IL-6 Recombinant Protein

Código de producto. p-7219989
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Cantidad:
5 x 5 μg
50 μg
Tamaño de la unidad:
50 microgramos
paquete de 5
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Código de producto. 17144213

Marca: Invitrogen™ A42541

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Descripción

Recombinant Protein

Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P05231
Para utilizar con (aplicación) Control, Binding Assay, Bioactivity, Western Blot
Formulación PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
ID de gen (Entrez) 3569
Peso molecular 20.95 kDa
Nombre Human IL-6
Intervalo de pH 7.4
Método de purificación Purified
Cantidad 50 μg
Fuente E. coli
Requisitos de almacenamiento -20°C or -80°C if preferred
Estado normativo RUO
Alias de gen B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Nombre común IL-6
Símbolo de gen Il6
Actividad biológica 1. Immobilized Human IL-6 Recombinant Protein (at 2 μg/mL (100 μL/well) can bind Human IL-6 R hFc, the EC50 of Human IL-6 R hFc is 3.0-10.0 ng/mL 2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-0.8 ng/mL 3.Loaded Recombinant Human IL-6 R Protein, His Tag on His1K Biosensor, can bind Human IL-6 Recombinant Protein with an affinity constant of 0.165 μM as determined in BLI assay (Sartorius Octet RED384)(Routinely tested).)
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína Untagged
Secuencia Human IL-6, amino acids Val30-Met212 (Accession # NP_000591.1) with an N-terminal Met
Contenido y almacenamiento Includes 1 vial of lyophilized protein. Store at -20 °C.
Actividad 1. Immobilized Human IL-6 Recombinant Protein at 2 μg/mL (100 μL/well) can bind Human IL-6R hFc, the EC50 of Human IL-6R hFc is 3.0-10.0 ng/mL. 2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-0.8 ng/mL. 3.Loaded Recombinant Human IL-6R Protein, His Tag on His1K Biosensor, can bind Human IL-6 Recombinant Protein with an affinity constant of 0.165 μM as determined in BLI assay (Sartorius Octet RED384)(Routinely tested).
Sistema de expresión E. coli
Familia de proteínas Cytokines & Receptors
Forma de proteína Full Length, Recombinant
Formulario Lyophilized
Subtipo de proteína Interleukins
Categoría de investigación Immunology, Inflammation, Oncology
Grado de pureza o calidad >95% by SDS-PAGE
Expresión interleukin 6 (interferon, beta 2)
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