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Gibco™ Human IL-4 Recombinant Protein

Código de producto. 10474553
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Cantidad:
100 μg
10 μg
1 mg
25 μg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10474553 10 μg cada uno
10069352 100 μg cada uno
10474363 1 mg cada uno
10593765 25 μg cada uno
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Código de producto. 10474553

Marca: Gibco™ PHC0044

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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, deionized water to 0.1-1.0 mg/mL to regain full activity. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in low endotoxin medium or buffered solution with FCS or tissue culture grade BSA. Storage Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P05112
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 3565
Peso molecular 14.9 kDa
Nombre Human IL-4
Método de purificación Purified
Cantidad 10 μg
Requisitos de almacenamiento 4°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Nombre común IL-4
Símbolo de gen Il4
Actividad biológica ED50 = 0.05 - 0.4 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS
Contenido y almacenamiento 4°C
Clasificación Carrier-Free
Actividad ED50 = 0.05 - 0.4 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Wet Ice
Sistema de expresión E. coli
Familia de proteínas Cytokines & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína Interleukins
Categoría de investigación Immunology, Stem Cell Research, Inflammation
Línea de productos Gibco
Grado de pureza o calidad >95% by SDS-PAGE
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