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Invitrogen™ Human IgG1 (103 Cys/Ser) Fc Chimera Recombinant Protein

Código de producto. 17184223
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Cantidad:
5 x 50 μg
5 x 5 μg
50 μg
5 μg
Tamaño de la unidad:
5 microgramos
50 microgramos
paquete de 5
Código de producto. Cantidad unitSize
17184223 5 μg 5 microgramos
17174223 5 x 50 μg paquete de 5
17164223 5 x 5 μg paquete de 5
17194223 50 μg 50 microgramos
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Código de producto. 17184223

Marca: Invitrogen™ A42560

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Descripción

Recombinant Protein

Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). [UniProt].
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P01857
Para utilizar con (aplicación) Control, ELISA Standard, Binding Assay, Western Blot
Formulación PBS with 0.01% Tween 80, 5% mannitol, 5% trehalose and no preservative; pH 7.4
ID de gen (Entrez) 3500
Peso molecular 26 kDa
Nombre Human IgG1 (103 Cys/Ser) Fc Chimera
Intervalo de pH 7.4
Método de purificación Purified
Cantidad 5 μg
Fuente HEK293 cells
Requisitos de almacenamiento -20°C or -80°C if preferred
Estado normativo RUO
Concentración de endotoxinas <1.0 EU/μg
Alias de gen IgG1; IgG3; Igh-4; Ighg; IGHG1; IGHG2; IGHG3; IGHG4; Immunoglobulin heavy chain (gamma polypeptide); immunoglobulin heavy constant gamma 1 (G1m marker); immunoglobulin heavy constant gamma 2 (G2m marker); immunoglobulin heavy constant gamma 3 (G3m marker); immunoglobulin heavy constant gamma 4 (G4m marker); RGD1359539; VH7183
Nombre común IGHG1
Símbolo de gen IGHG1
Actividad biológica 1. Measured by its ability to bind human CD16a-His in a functional ELISA. 2. Measured by its ability to bind human CD16a-AVI-His in a functional ELISA. 3.Measured by its ability to bind human CD16a-His in a functional ELISA.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína IgG1 Fc Tag
Secuencia Human IgG1 Fc, amino acids Glu99-Lys330 (Accession # P01857-1) with a single mutation C103S
Contenido y almacenamiento Store at -20 to -70 °C
Actividad 1. Measured by its ability to bind human CD16a-His in a functional ELISA.<br><br>2. Measured by its ability to bind human CD16a-AVI-His in a functional ELISA.<br><br>3.Measured by its ability to bind human CD16a-His in a functional ELISA.
Nivel de endotoxinas < 1 EU/μg
Condiciones de envío Room Temperature
Sistema de expresión HEK293 cells
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Truncated
Formulario Lyophilized
Subtipo de proteína Other Proteins
Categoría de investigación Immunology, Inflammation
Grado de pureza o calidad ≥95 % as determined by SDS-PAGE. ≥95 % as determined by SEC-HPLC.
Expresión Fc region of human immunoglobulin G1
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