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Gibco™ Human IGF-II Recombinant Protein

Código de producto. 10232543
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Cantidad:
50 μg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10232543 50 μg cada uno
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Código de producto. 10232543

Marca: Gibco™ PHG0084

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Descripción

Recombinant Protein

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile, distilled water, to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2°C to 8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein, such as 0.1% BSA and store in working aliquots at -20°C to -80°C. Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C for long term storage, preferably desiccated. Working aliquots stored with a carrier protein are stable for at least 12 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles.

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P01344
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 3481
Peso molecular 7.5 kDa
Nombre Human IGF-II
Método de purificación Purified
Cantidad 50 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen AL033362; C11orf43; FLJ22066; FLJ44734; GRDF; H-IGF-2; IGF; Igf2; Igf-2; IGFII; Igf-II; Insulin like growth factor; insulin like growth factor 2; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); Insulin-like growth factor II Ala-25 Del; insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; M6pr; Mpr; MSA; multiplication-stimulating activity; Multiplication-stimulating polypeptide; Peg2; PP1446; PP9974; preptin; RNIGF2; Somatomedin-A; T3M-11-derived growth factor
Nombre común IGF2
Símbolo de gen IGF2
Actividad biológica ED50 ≤ 2 ng/mL; determined by the dose-dependent proliferation of FDC-P1 cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE
Contenido y almacenamiento -20°C
Actividad ED50 ≤ 2 ng/mL; determined by the dose-dependent proliferation of FDC-P1 cells.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión E. coli
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína IGFs (Insulin-Like Growth Factors)
Categoría de investigación Oncology, Signal Transduction
Línea de productos Gibco
Grado de pureza o calidad ≥98% by SDS-PAGE and HPLC
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