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Invitrogen™ Human ICAM-1 (CD54) Recombinant Protein
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Cantidad:
10 μg
Tamaño de la unidad:
10 microgramos
Descripción
RP-75641 contains purified recombinant human ICAM-1 protein with an N-terminal hexahistidine tag. RP-75641 may be used as a positive control in many immunological assays.
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Especificaciones
Especificaciones
| Número de acceso | P05362 |
| Concentración | 0.165 mg/mL |
| Para utilizar con (aplicación) | Control, Western Blot |
| Formulación | 20 mM tris HCl, PBS with 50% glycerol and no preservative; pH 8 |
| ID de gen (Entrez) | 3383 |
| Nombre | Human ICAM-1 (CD54) |
| Intervalo de pH | 8.0 |
| Cantidad | 10 μg |
| Fuente | E. coli |
| Inmunógeno | N/A |
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