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Invitrogen™ Human HAP40 (aa 279-371) Control Fragment Recombinant Protein
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
Descripción
Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61382 (PA5-61382. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Huntington's disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the Huntington protein. Huntington co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of Huntington but is actively targeted to the nucleus in the absence of Huntington. These observations suggest that HAP40°Contributes to the function of normal Huntington and is a candidate for involvement in the aberrant nuclear localization of mutant Huntington found in degenerating neurons in Huntington's disease.
Especificaciones
Especificaciones
| Número de acceso | P23610 |
| Concentración | ≥5.0 mg/mL |
| Para utilizar con (aplicación) | Blocking Assay, Control |
| Formulación | 1 M urea, PBS with no preservative; pH 7.4 |
| ID de gen (Entrez) | 474383, 474384, 8263 |
| Nombre | Human HAP40 (aa 279-371) Control Fragment |
| Cantidad | 100 μL |
| Estado normativo | RUO |
| Alias de gen | 40-kDa huntingtin-associated protein; AI852759; coagulation factor VIII-associated (intronic transcript) 1; coagulation factor VIII-associated 1; cpG island protein; DXS522E; DXUcsf1; F8A; F8A1; F8A2; F8A3; factor 8-associated gene A; Factor VIII associated protein; factor VIII intron 22 protein; HAP40; huntingtin-associated protein 40; RP23-114O19.4 |
| Nombre común | HAP40 |
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