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Gibco™ Human GDF-15/MIC-1 Recombinant Protein, PeproTech®

Código de producto. 17810303
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Cantidad:
100 μg
1 mg
20 μg
250 μg
500 μg
5 μg
Tamaño de la unidad:
1 miligramo
100 microgramos
20 microgramos
250 microgramos
5 microgramos
500 microgramos
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Código de producto. Cantidad unitSize
17810303 100 μg 100 microgramos
17851533 1 mg 1 miligramo
17860963 20 μg 20 microgramos
17860573 250 μg 250 microgramos
17820973 500 μg 500 microgramos
17861363 5 μg 5 microgramos
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Código de producto. 17810303 Proveedor Gibco™ N.º de proveedor 12028C100UG

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Beschreibung

Recombinant Protein

Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
TRUSTED_SUSTAINABILITY

Spezifikation

Número de acceso Q99988
Para utilizar con (aplicación) Functional Assay
Formulación protein with no preservative
ID de gen (Entrez) 9518
Peso molecular 24.6 kDa
Nombre Human GDF-15/MIC-1
Cantidad 100 μg
Fuente CHO cells
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen Gdf15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1; MIC1; MIC-1; NAG1; NAG-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; placental TGF-beta; Prostate differentiation factor; PTGFB; PTGF-beta; SBF
Nombre común GDF15
Símbolo de gen Gdf15
Actividad biológica Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osteoblastcells. The expected ED50 for this effect is 75-200 ng/ml
Conjugado Unconjugated
Recombinante Recombinant
Secuencia ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
Contenido y almacenamiento -20°C
Sistema de expresión CHO cells
Formulario Lyophilized
Grado de pureza o calidad ≥ 95% by SDS-PAGE gel and HPLC analyses.
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