missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Proteínas recombinantes
  4. Gibco™ Human Furin Recombinant Protein, PeproTech®

Gibco™ Human Furin Recombinant Protein, PeproTech®

Código de producto. 17884743
Change view
Click to view available options
Cantidad:
10 x 50 μg
10 μg
2 x 50 μg
20 × 50 μg
2 μg
5 x 50 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
2 microgramos
250 microgramos
50 microgramos
500 microgramos
Código de producto. Cantidad unitSize
17884743 10 μg 10 microgramos
17883903 2 x 50 μg 100 microgramos
17824743 20 × 50 μg 1 miligramo
17864663 5 x 50 μg 250 microgramos
17874253 2 μg 2 microgramos
17814193 10 x 50 μg 500 microgramos
17804033 50 μg 50 microgramos
7 options
Este artículo no se puede devolver. Vea la política de devoluciones

Código de producto. 17884743

Marca: Gibco™ 4504710UG

Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.

Este artículo no se puede devolver. Vea la política de devoluciones

Descripción

Recombinant Protein

450-47-100UG will be provided as 2 x 50 μg (450-47-50UG). 450-47-1MG will be provided as 20 x 50 μg (450-47-50UG). 450-47-250UG will be provided as 5 x 50 μg (450-47-50UG). 450-47-500UG will be provided as 5 x 100 μg (450-47-50UG). Recombinant Human Furin is a 63.9 kDa protein, corresponding to residues 131 through 715 of the Furin precursor, plus a C-terminal His-tag. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ∽10 kDa amino-terminal proregion, a highly conserved ∽55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P09958
Para utilizar con (aplicación) Functional Assay
Formulación protein with no preservative
ID de gen (Entrez) 5045
Peso molecular 63.9 kDa
Nombre Human Furin
Cantidad 10 μg
Fuente Insect cells
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen 9130404I01Rik; dibasic processing enzyme; dibasic-processing enzyme; FES upstream region; FUR; Furin; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; furin, paired basic amino acid cleaving enzyme; furin; LOW QUALITY PROTEIN: furin; Pace; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme; Pcsk3; prohormone convertase 3; proprotein convertase subtilisin/kexin type 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3; SPC1; subtilisin pro-protein processing enzyme
Nombre común Furin
Símbolo de gen FURIN
Actividad biológica Measured by its ability to cleave the fluorogenic peptide substrate Boc-Arg-Val-Arg-Arg-AMC (Bachem Catalog# I-1645.0025).
Conjugado Unconjugated
Recombinante Recombinant
Etiqueta de proteína His-tag
Secuencia DLNVKAAWAQ GYTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNAND WATNGVGRKV SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IIDILTEPKD IGKRLEVRKT VTACLGEPNH ITRLEHAQAR LTLSYNRRGD LAIHLVSPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD EDPSGEWVLE IENTSEANNY GTLTKFTLVL YGTAPEGLPV PPESSGCKTL TSSQACVVCE EGFSLHQKSC VQHCPPGFAP QVLDTHYSTE NDVETIRASV CAPCHACSAT CQGPALTDCL SCPSHASLDP VEQTCSRQSQ SSRESPPQQQ PPRLPPEVEA GQRLRAGLLP SHLPEHHHHH HHH
Contenido y almacenamiento -20°C
Sistema de expresión Insect cells
Formulario Lyophilized
Grado de pureza o calidad ≥ 95% by SDS-PAGE gel and HPLC analyses.
Mostrar más Mostrar menos
Título del producto
Seleccione un problema

Al hacer clic en Enviar, acepta que Fisher Scientific se ponga en contacto con usted en relación con los comentarios que ha proporcionado en este formulario. No compartiremos su información para ningún otro fin. Toda la información de contacto proporcionada se mantendrá de acuerdo con nuestra Política de Privacidad. Política de privacidad.