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Gibco™ Human FGF-basic (FGF-2/bFGF) (aa 1-155) Recombinant Protein

Código de producto. 10282993
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Cantidad:
100 μg
10 μg
1 mg
25 μg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10282993 1 mg cada uno
10542415 100 μg cada uno
10008002 10 μg cada uno
10170073 25 μg cada uno
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Product Code. 10282993

Brand: Gibco™ PHG0263

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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to a concentration of 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium, or buffered solution containing carrier protein (e.g., PBS with 0.1% BSA). Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P09038
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 2247
Peso molecular 17.2 kDa
Nombre Human FGF-basic (FGF-2/bFGF) (aa 1-155)
Método de purificación Purified
Cantidad 1 mg
Requisitos de almacenamiento 4°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Nombre común FGF2
Símbolo de gen FGF2
Actividad biológica ED50 = 0.1 - 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia Human FGF-basic, amino acids Met134-Ser288 with C211S and C229S substitutions and an N-terminal Gly-His
Contenido y almacenamiento 4°C
Actividad ED50 = 0.1 - 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión E. coli
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína FGFs (Fibroblast Growth Factors)
Categoría de investigación Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Línea de productos Gibco
Grado de pureza o calidad >95% by SDS-PAGE
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