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Invitrogen™ Human DIS3 (aa 849-943) Control Fragment Recombinant Protein
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
Descripción
Highest antigen sequence indentity to the following orthologs: Mouse (86%), Rat (86%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58723 (PA5-58723. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
Especificaciones
Especificaciones
| Número de acceso | Q9Y2L1 |
| Concentración | ≥5.0 mg/mL |
| Para utilizar con (aplicación) | Blocking Assay, Control |
| Formulación | 1 M urea, PBS with no preservative; pH 7.4 |
| ID de gen (Entrez) | 22894 |
| Nombre | Human DIS3 (aa 849-943) Control Fragment |
| Cantidad | 100 μL |
| Estado normativo | RUO |
| Alias de gen | 2810028N01Rik; bA555G22.1; DIS3; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog; DIS3 mitotic control homolog (S. cerevisiae); dis3p; EXOSC11; exosome complex exonuclease RRP44; exosome component 11; KIAA1008; mitotic control protein dis3 homolog; protein DIS3 homolog; RGD1304646; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44 |
| Nombre común | DIS3 |
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