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Gibco™ Human CD200 Fc Recombinant Protein, PeproTech®

Product Code. 17994342
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Cantidad:
100 μg
10 μg
1 mg
250 μg
500 μg
50 μg
Unit Size:
1 miligramo
10 microgramos
100 microgramos
250 microgramos
50 microgramos
500 microgramos
Product Code. Cantidad unitSize
17994342 50 μg 50 microgramos
17964202 500 μg 500 microgramos
17934182 250 μg 250 microgramos
17954202 1 mg 1 miligramo
17974202 10 μg 10 microgramos
17904342 100 μg 100 microgramos
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Product Code. 17994342

Brand: Gibco™ 3104650UG

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Description

Recombinant Protein

Recombinant Human CD200 Fc is a 97.0 kDa homodimeric protein of 435 amino acids consisting of the extracellular domain of the mature sequence, as well as a 230-residue C-terminal Fc region linked by two glycines. As a result of glycosylation, the Recombinant Human CD200 Fc migrates to an apparent molecular weight of approximately 60-70 kDa by SDS-PAGE gel, under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P41217
Para utilizar con (aplicación) Functional Assay
Formato Lyophilized
Formulación protein with no preservative
ID de gen (Entrez) 4345
Peso molecular 48.5 kDa
Nombre Human CD200 Fc
Cantidad 50 μg
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-O x 2); Cspmo2; hypothetical protein LOC534910; MO x 1; MO x 2; MRC; MRC OX-2 antigen; MRCO x 2; My033; O x 2; OX-2; OX-2 membrane glycoprotein
Nombre común CD200
Actividad biológica Determined by its ability to bind Human CD200 R1 Fc in a functional ELISA.
Conjugado Unconjugated
Recombinante Recombinant
Etiqueta de proteína Fc-tag
Secuencia Monomer: QVQVVTQDER EQLYTPASLK CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGGGPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
Contenido y almacenamiento -20°C
Sistema de expresión CHO cells
Formulario Lyophilized
Grado de pureza o calidad ≥ 95% by SDS-PAGE gel and HPLC analyses.
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