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Gibco™ Human CCL19 (MIP-3 beta) Recombinant Protein, PeproTech®

Código de producto. 17822353
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Cantidad:
100 μg
2 x 500 μg
20 μg
250 μg
500 μg
50 μg
5 μg
Unit Size:
1 miligramo
100 microgramos
20 microgramos
250 microgramos
5 microgramos
50 microgramos
500 microgramos
Product Code. Cantidad unitSize
17822353 500 μg 500 microgramos
17892883 100 μg 100 microgramos
17872383 2 x 500 μg 1 miligramo
17822763 20 μg 20 microgramos
17802993 250 μg 250 microgramos
17862383 50 μg 50 microgramos
17842353 5 μg 5 microgramos
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Product Code. 17822353

Brand: Gibco™ 30029B500UG

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Description

Recombinant Protein

300-29B-1MG will be provided as 2 x 500 μg (300-29B-500UG). Recombinant Human MIP-3beta is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso Q99731
Para utilizar con (aplicación) ELISA, Functional Assay, Western Blot
Formulación protein with no preservative
ID de gen (Entrez) 6363
Peso molecular 8.8 kDa
Nombre Human CCL19 (MIP-3 beta)
Cantidad 500 μg
Fuente E. coli
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen beta chemokine exodus-3; beta-chemokine exodus-3; CC chemokine ligand 19; C-C motif chemokine; C-C motif chemokine 19; C-C motif chemokine ligand 19; Ccl19; chemokine (C-C motif) ligand 19; chemokine CCL19; CK beta-11; CKb11; EBI1 ligand chemokine; EBI-1 ligand chemokine; EBI1-ligand chemokine; EBV-induced molecule 1 ligand chemokine; ELC; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP3B; MIP-3 b; MIP-3-beta; M-MIP-3-beta; SCYA19; small inducible cytokine A19; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
Nombre común CCL19
Símbolo de gen Ccl19
Actividad biológica Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml
Conjugado Unconjugated
Recombinante Recombinant
Secuencia GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
Contenido y almacenamiento -20°C
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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