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Gibco™ Human BDNF Recombinant Protein

Código de producto. 10477253
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Cantidad:
10 μg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10477253 10 μg cada uno
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Código de producto. 10477253

Marca: Gibco™ PHC7074

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685.90 EUR hasta el 2026-02-28
MEJOR PRECIO en promoción! Use el código promocional "28033" para aplicar la oferta.
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Descripción

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute BDNF in sterile, distilled water to a concentration of 0.1-1.0 mg/mL. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing carrier protein, such as 0.1% BSA and store in working aliquots from -20°C to -80°C. Storage: The lyophilized protein is stable at room temperature for up to 1 month, but should be kept at -20°C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2°C to 8°C. Working aliquots stored with a carrier protein are stable for at least 12 months at -20°C to -80°C. Avoid repeated freeze-thaw cycles.

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P23560
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 627
Peso molecular 27 kDa
Nombre Human BDNF
Método de purificación Purified
Cantidad 10 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Nombre común BDNF
Símbolo de gen BDNF
Actividad biológica ED50 = 0.5 - 1.0 μg/mL; determined by the dose-dependent proliferation of rat C6 cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia Human BDNF recombinant protein is a homodimer containing two 120 amino acid subunits linked by hydrophobic interaction
Contenido y almacenamiento -20°C
Clasificación Carrier-Free
Actividad ED50 = 0.5 - 1.0 μg/mL; determined by the dose-dependent proliferation of rat C6 cells.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión E. coli
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína Neurotrophic Factors
Categoría de investigación Neurobiology, Stem Cell Research, Differentiation
Línea de productos Gibco
Grado de pureza o calidad ≥98% by SDS-PAGE and HPLC
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