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HLA-DR Antibody (LN-3), PE, Novus Biologicals™
Mouse Monoclonal Antibody
Marca: Novus Biologicals NBP2-47670PE
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Descripción
HLA-DR Monoclonal specifically detects HLA-DR in Human, Monkey, Mouse (Negative) samples. It is validated for Flow Cytometry.
Especificaciones
| HLA-DR | |
| Monoclonal | |
| PE | |
| PBS with 0.05% Sodium Azide | |
| HLA-DRA | |
| Activated human peripheral blood mononuclear cells | |
| 0.1 mL | |
| Primary | |
| This monoclonal antibody reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each others respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. | |
| Store at 4C in the dark. | |
| IgG2b κ |
| Flow Cytometry | |
| LN-3 | |
| Flow Cytometry | |
| FLJ51114, histocompatibility antigen HLA-DR alpha, HLA class II histocompatibility antigen, DR alpha chain, HLA-DRA1, major histocompatibility complex, class II, DR alpha, MHC cell surface glycoprotein, MHC class II antigen DRA, MLRW | |
| Mouse | |
| Protein A or G purified | |
| Adaptive Immunity, B Cell Development and Differentiation Markers, Cell Biology, Cellular Markers, Diabetes Research, Immunology, Major Histocompatibility Complexes | |
| 3122 | |
| Human, Monkey, Mouse (Negative) | |
| Purified |
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