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FoxP3 Antibody (FXP3/197), Alexa Fluor™ 532, Novus Biologicals™

Código de producto. 18124883 Tienda Bio Techne Productos
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Cantidad:
0.1 mL
Tamaño de la unidad:
0.10 ml
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18124883 0.1 mL 0.10 ml
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Código de producto. 18124883 Proveedor Novus Biologicals N.º de proveedor NBP234620AF532

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Descripción

Mouse Monoclonal Antibody

FoxP3 Monoclonal specifically detects FoxP3 in Human, Mouse, Monkey samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno FoxP3
Aplicaciones Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Clasificación Monoclonal
Clon FXP3/197
Conjugado Alexa Fluor 532
Dilución Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Formulación 50 mM sodium borate with 0.05% sodium azide
Alias de gen AIID, AIIDMGC141961, DIETER, forkhead box P3, Forkhead Box Protein P3, FOXP3delta7, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked, IPEX, JM2, MGC141961, MGC141963, PIDX, PIDXMGC141963, Scurfin, XPID, XPIDpolyendocrinopathy, enteropathy, X-linked
Símbolos de los genes FOXP3
Especie del huésped Mouse
Inmunógeno Recombinant human full-length FoxP3 protein (Uniprot: Q9ZS1)
Método de purificación Protein A or G purified
Cantidad 0.1 mL
Disciplina de investigación Adaptive Immunity, Cell Biology, Chromatin Research, Immunology, Regulatory Immunology, Transcription Factors and Regulators
Primario o secundario Primary
ID de gen (Entrez) 50943
Especificidad de la prueba Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
Especies diana Human, Mouse, Primate
Contenido y almacenamiento Store at 4°C in the dark.
Isotype IgG1 κ
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