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ETS1 associated protein II Antibody (TDP2/1258), DyLight 350, Novus Biologicals™

Código de producto. 18164688 Tienda Bio Techne Productos
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Cantidad:
0.1 mL
Tamaño de la unidad:
0.10 ml
Código de producto. Cantidad unitSize
18164688 0.1 mL 0.10 ml
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Código de producto. 18164688

Marca: Novus Biologicals NBP250071UV

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Descripción

Mouse Monoclonal Antibody

ETS1 associated protein II Monoclonal specifically detects ETS1 associated protein II in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno ETS1 associated protein II
Aplicaciones Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Clasificación Monoclonal
Clon TDP2/1258
Conjugado DyLight 350
Dilución Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulación 50mM Sodium Borate with 0.05% Sodium Azide
Alias de gen AD022, dJ30M3.3, EAP2, EAPII, EC 3.1.4.-, ETS1-associated protein 2, ETS1-associated protein II, MGC111021,5'-Tyr-DNA phosphodiesterase, MGC9099,5'-tyrosyl-DNA phosphodiesterase, TRAF and TNF receptor associated protein, TTRAPTRAF and TNF receptor-associated protein, Tyr-DNA phosphodiesterase 2, tyrosyl-DNA phosphodiesterase 2
Símbolos de los genes TDP2
Especie del huésped Mouse
Inmunógeno Recombinant full-length human ETS1 associated protein II protein (Uniprot: O95551)
Método de purificación Protein A or G purified
Cantidad 0.1 mL
Estado normativo RUO
Disciplina de investigación Signal Transduction, Transcription Factors and Regulators
Primario o secundario Primary
Especificidad de la prueba This MAb recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Especies diana Human
Contenido y almacenamiento Store at 4°C in the dark.
Isotype IgG2b κ
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