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Invitrogen™ Estrogen Receptor alpha (ER alpha) ER Alpha Recombinant Protein

Código de producto. 15315806
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Cantidad:
140 μg
Tamaño de la unidad:
cada uno
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Código de producto. 15315806

Marca: Invitrogen™ A15674

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Descripción

Includes

One tube of full-length ER Alpha Recombinant Protein.

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. ER (Estrogen Receptor) Alpha Recombinant Protein is an insect cell-expressed, full-length, untagged, human nuclear hormone receptor that binds [3H]-estradiol with sub-nM affinity in hydroxylapatite assays and binds specifically to estrogen response element (ERE) sequences. ER alpha full-length recombinant protein is: Flexible-use in your in-house assay or as part of our PolarScreen™ ER Alpha Competitor assays for a complete assay solution Ready to use-active, purified, and native (untagged) Convenient-available in bulk sizes ER Alpha Recombinant Protein is manufactured under the strictest quality parameters. This product is guaranteed for 6 months after purchase. Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond. Used in:PolarScreen™ ER Alpha Competitor Assay, RedPolarScreen™ ER Alpha Competitor Assay, Green Protein Form: Recombinant, Full Length.

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P03372
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación Proprietary buffer with no preservative
ID de gen (Entrez) 2099
Peso molecular 66.4 kDa
Nombre Estrogen Receptor alpha (ER alpha) ER Alpha
Método de purificación Purified
Cantidad 140 μg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product
Nombre común Estrogen Receptor alpha
Símbolo de gen ESR1
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Sistema de expresión Insect cells
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Full Length
Formulario Liquid
Categoría de investigación Signal Transduction
Grado de pureza o calidad 80% as determined by a SDS-PAGE gel stained with SimplyBlueTM SafeStain.
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