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  4. Invitrogen™ Human EIF2AK3 (PERK), GST Tag Recombinant Protein

Invitrogen™ Human EIF2AK3 (PERK), GST Tag Recombinant Protein

Código de producto. p-7121730
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Cantidad:
100 μg
10 μg
Tamaño de la unidad:
100 microgramos
cada uno
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Artikelnummer. 15438703

Brand: Invitrogen™ PR8985A

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Beskrivelse

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
TRUSTED_SUSTAINABILITY

Tekniske data

Número de acceso Q9NZJ5
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50mM tris with 2mM DTT, 0.5mM EDTA, 50% glycerol, 0.02% Triton X-100, 150mM NaCl and no preservative; pH 7.5
ID de gen (Entrez) 9451
Peso molecular 93.6 kDa
Nombre Human EIF2AK3 (PERK), GST Tag
Intervalo de pH 7.5
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Nombre común PERK
Símbolo de gen EIF2AK3
Familia Quinasa PEK Kinase Family
Longitud de la proteína 536-1116
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína GST-tag
Secuencia 536-1116
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Grupo de cinasas Ser⁄Thr Kinases: Other
Condiciones de envío Dry Ice
Sistema de expresión Insect cells
Familia de proteínas Kinases & Inhibitors
Forma de proteína Recombinant, Catalytic
Formulario Liquid
Categoría de investigación Signal Transduction
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