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Invitrogen™ Human EIF2AK3 (PERK), GST Tag Recombinant Protein
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Cantidad:
100 μg
10 μg
Tamaño de la unidad:
100 microgramos
cada uno
Descripción
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
Especificaciones
Especificaciones
| Número de acceso | Q9NZJ5 |
| Concentración | See Label |
| Para utilizar con (aplicación) | Kinase Assay |
| Formulación | 50mM tris with 2mM DTT, 0.5mM EDTA, 50% glycerol, 0.02% Triton X-100, 150mM NaCl and no preservative; pH 7.5 |
| ID de gen (Entrez) | 9451 |
| Peso molecular | 93.6 kDa |
| Nombre | Human EIF2AK3 (PERK), GST Tag |
| Intervalo de pH | 7.5 |
| Método de purificación | Purified |
| Cantidad | 100 μg |
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